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Relevant PublicationsJACS 2010Chen, J., Armstrong, A., Koehler, A., Hecht, M. Small Molecule Microarrays Enable the Discovery of Compounds That Bind the Alzheimer’s Aβ Peptide and Reduce its Cytotoxicity. Journal of the American Chemical Society, 2010.PNAS 2010Clemonsa, P., Bodycombea, N., Carrinskia, H., Wilsona, A., Shamjia, A., Wagnera, B., Koehler, A., Schreiber, S. Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles. Proceedings of the National Academy of Sciences, 2010.Nature 2009Stanton, B., Peng, L., Maloof, N., Nakai, K., Wang, X., Duffner, J., Taveras, K., Hyman, J., Lee, S., Koehler, A., Chen, J., Fox, J., Mandinova, A., Schreiber, S. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nature Chemical Biology, 2009.ChemSocRev 2008Vegas, A., Fuller, J., and Koehler, A. Small-molecule microarrays as tools in ligand discovery. Chemical Society Review, 2008.Angewandte Chemie 2007Vegas, A., Bradner, J., Tang, W., McPherson, O., Greenberg, E., Koehler, A., Schreiber, S. Fluorous-Based Small-Molecule Microarrays for the Discovery of Histone Deacetylase Inhibitors. Angewandte Chemie International Edition, 2007.Nature Protocols 2006Bradner, J., McPherson, O., Koehler, A. A method for the covalent capture and screening of diverse small molecules in a microarray format. Nature Protocols, 2006.Chemistry & Biology 2006Bradner, J., McPherson, O., Mazitschek, R., Barnes-Seeman, D., Shen, J., Dhaliwal, J., Stevenson, K., Duffner, J., Park, S., Neuberg, D., Nghiem, P., Schreiber, S., Koehler, A. A Robust Small-Molecule Microarray Platform for Screening Cell Lysates. Chemistry and Biology, 2006.JACS 2003Koehler, A., Shamji, A., Schreiber, S. Discovery of an Inhibitor of a Transcription Factor Using Small Molecule Microarrays and Diversity-Oriented Synthesis. Journal of the American Chemical Society, 2003.Nature 2002Kuruvilla, F., Shamji, A., Sternson, S., Hergenrother, P., Schreiber, S. Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays. Nature, 2002.JACS 1999MacBeath, G., Koehler, A., Schreiber, S. Printing Small Molecules as Microarrays and Detecting Protein−Ligand Interactions en Masse. Journal of the American Chemical Society, 1999. |